CLINICAL TRIALS AND OBSERVATIONS Improved outcome with pulses of vincristine and corticosteroids in continuation therapy of children with average risk acute lymphoblastic leukemia (ALL) and lymphoblastic non-Hodgkin lymphoma (NHL): report of the EORTC randomized phase 3 trial 58951

نویسندگان

  • Barbara De Moerloose
  • Stefan Suciu
  • Yves Bertrand
  • Françoise Mazingue
  • Alain Robert
  • Anne Uyttebroeck
  • Karima Yakouben
  • Geneviève Margueritte
  • Patrick Lutz
  • Martine Munzer
  • Nicolas Sirvent
  • Lucilia Norton
  • Patrick Boutard
  • Dominique Plantaz
  • Frederic Millot
  • Pierre Philippet
  • Liliana Baila
  • Yves Benoit
چکیده

Barbara De Moerloose,1 Stefan Suciu,2 Yves Bertrand,3 Françoise Mazingue,4 Alain Robert,5 Anne Uyttebroeck,6 Karima Yakouben,7 Alice Ferster,8 Geneviève Margueritte,9 Patrick Lutz,10 Martine Munzer,11 Nicolas Sirvent,12 Lucilia Norton,13 Patrick Boutard,14 Dominique Plantaz,15 Frederic Millot,16 Pierre Philippet,17 Liliana Baila,2 Yves Benoit,1 and Jacques Otten,18 for the Children’s Leukemia Group (CLG) of the European Organisation for Research and Treatment of Cancer (EORTC)

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

CLINICAL TRIALS AND OBSERVATIONS Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents

Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents Mitchell S. Cairo,1 Mary Gerrard,2 Richard Sposto,3 Anne Auperin,4 C. Ross Pinkerton,5 Jean Michon,6 Claire Weston,7 Sherrie L. Perkins,8 Martine Raphael,9 Keith McCarthy,10 and Catherine Patte,4 on behalf of the FAB LMB96 Internat...

متن کامل

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Improved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children’s Research Hospital

St Jude Total Therapy Study XIIIB for childhood acute lymphoblastic leukemia (ALL) incorporated more stringent risk classification, early intensification of intrathecal chemotherapy, reinduction treatment, and the addition of dexamethasone to postremission therapy to increase the proportion of event-free survivors without jeopardizing their quality of life. Cranial irradiation was reserved for ...

متن کامل

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Comparison of Escherichia coli–asparaginase with Erwinia-asparaginase in the treatment of childhood lymphoid malignancies: results of a randomized European Organisation for Research and Treatment of Cancer—Children’s Leukemia Group phase 3 trial

Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has minimal bone marrow toxicity. Its major side effects are anaphylaxis, pancreatitis, diabetes, coagulation abnormalities, and thrombosis, especially intracranial. It is derived from 2 different sources: Escherichia coli and Erwinia chrysanthemi. Nonrandomized clinical st...

متن کامل

CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Clinical importance of minimal residual disease in childhood acute lymphoblastic leukemia

By using rapid flow cytometric techniques capable of detecting one leukemic cell in 104 normal cells, we prospectively studied minimal residual disease (MRD) in 195 children with newly diagnosed acute lymphoblastic leukemia (ALL) in clinical remission. Bone marrow aspirates (n 5 629) were collected at the end of remission induction therapy and at 3 intervals thereafter. Detectable MRD (ie, >0.0...

متن کامل

CLINICAL TRIALS AND OBSERVATIONS Acute mixed lineage leukemia in children: the experience of St Jude Children’s Research Hospital

To characterize the biology and optimal therapy of acute mixed-lineage leukemia in children, we reviewed the pathologic and clinical features, including response to therapy, of 35 patients with mixedlineage leukemia. The majority of cases (91%) had blasts cells that simultaneously expressed either T-lineage plus myeloid markers (T/myeloid, n 20) or B-lineage plus myeloid markers (B/myeloid, n 1...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2010